Curvularia lunata: A fungus for possible berberine transformation

The prevalence of multidrug-resistant microorganisms results in an urgent need for the development new antimicrobial agents or treatment strategies. In this sense, plants serve different alternatives. Berberine, a plant-derived compound, is one alkaloids known to display activity against several types microorganisms, while its being substrate various efflux pumps causes decrease efficacy. Biotransformation makes it possible obtain novel more effective compounds with only minor structural modifications using enzyme systems. study, biotransformation berberine by Curvularia lunata was examined. working concentration determined observing microbial growth on agar plates. residual media analyzed HPLC. addition, laccase and beta-glucosidase activities were followed their roles during berberine. show that at end 14 days, C. consumed 99% 87% initial concentrations 0.35 mg/mL 0.5 mg/mL, respectively. Enzyme not affected significantly. Since decreased, could be mentioned. Monitoring products plays crucial role discovering valuable molecules.